| Source | M.W. | 421.52 | CAS No. | 909910-43-6 | |
|---|---|---|---|---|---|
| Structural Info | C25H19N5S |
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| Formulation | Powder | ||||
| Reconstitution | Before reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube. The compound is soluble in DMSO. | ||||
| Stability | The powder is stable for at least 2 year if stored at -20 °C. The dissolved compound is stable for at least 1 month at 4 °C, but should be stored in aliquots at -20 °C for longer term. Protect from light. | ||||
| Purity | Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request. | ||||
| Biological Activity | |||||
| Country of Origin | USA | ||||
A selective inhibitor of ALK-4 (Activin/Nodal receptor), ALK-5 (TGF-β type I receptor), and ALK-7 (nodal receptor). Only weakly inhibits ALK-1, -2, -3, and -6.
3-(6-METHYLPYRIDIN-2-YL)-1-PHENYLTHIOCARBAMOYL-4-QUINOLIN-4-YLPYRAZOLE
Ref: Tojo, M., et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 96: 791-800, 2005.