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  • THIA-001, 1 mg89.00
  • THIA-005, 5 mg189.00
  • THIA-025, 25 mg789.00
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Source M.W.311.36 CAS No.1226056-71-8
Structural InfoThiazovivin
ReconstitutionBefore reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube.  The compound is soluble in DMSO.
StabilityThe powder is stable for at least 1 year if stored at -20 °C.   The dissolved compound is stable for at least 1 month at 4 °C, but should be stored in aliquots at -20 °C for longer term. Protect from light.
PurityGreater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological ActivityTested active for culturing human iPS cells in serum-free medium on Matrigel coated plates.
Country of OriginUSA

Thiazovivin, N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide, is a selective inhibitor of Rho-associated kinase (ROCK).
It protects human ES cells from death in the absence of ECM by regulating E-cadherin mediated cell-cell interaction. Thiazovivin, in combination with inhibitors of the TGF-beta receptor and the MEK kinases, improves reprogramming efficiency dramatically.

Ref:  Lin, T., et al. (2009) A chemical platform for improved induction of human iPSCs. Nature Methods. 6(11):