$ 149.00

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  • SAG-001, 1 mg149.00
  • SAG-005, 5 mg449.00
  • SAG-025, 25 mg1349.00
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Source M.W.599 CAS No.364590-63-6
Structural InfoC28H28ClN3OS·2HCl·2H2O
FormulationSolution. 2.5 mg/mL in DMSO (4 mM)
ReconstitutionThe compound has been dissolved in DMSO.
StabilityThe powder is stable for at least 2 year if stored at -20 °C.   The dissolved compound is stable for at least 1 month at 4 °C, but should be stored in aliquots at -20 °C for longer term. Protect from light.
PurityGreater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological ActivityIn a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives EC50 of 2-10 nM.
Country of Origin

SAG is a highly potent agonist of SMO (smoothened).  This small molecule compound activates the hedgehog pathway by directly binding to SMO.

Note: in the Gli-1 reporter gene assay, SAG acts as an activator at concentrations from approximately 1 nM to 1 uM, but as an inhibitor at concentrations high than 1 uM.

Ref:  Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071