$ 99.00

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  • PUR-005, 5 mg99.00
  • PUR-025, 25 mg359.00
  • PUR-100, 100 mg1139.00
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Source M.W.520.6 CAS No.483367-10-8
Structural InfoC31H32N6O2

ReconstitutionBefore reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube. The compound is soluble in DMSO.
StabilityThe powder is stable for at least 2 year if stored at -20 °C. The dissolved compound is stable for at least 1 month at 4 °C, but should be stored in aliquots at -20 °C for longer term. Protect from light.
PurityGreater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological ActivityIn a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives EC50 of 1.0 uM.
Country of OriginUSA

Purmorphamine is an agonist of SMO (smoothened).  This small molecule compound activates the hedgehog pathway by directly binding to SMO.  It has been shown to induce osteogenesis of mesenchymal stem cells.

Ref:  Wu, X., et al. 2004. Chem. Biol. 11: 1229;  Sinha, S.
Chen, J.K. 2006. Nat. Chem. Biol. 2: 29