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  • PD-002, 2 mg59.00
  • PD-010, 10 mg159.00
  • PD-050, 50 mg459.00
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Source M.W.482.19 CAS No.391210-10-9
ReconstitutionBefore reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube.  The compound is soluble in DMSO.
StabilityThe powder is stable for at least 2 year if stored at -20 °C. The dissolved compound is stable for at least 1 month at 4 °C, but should be stored in aliquots at -20 °C for longer term. Protect from light.
PurityGreater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity
Country of OriginUSA

A selective inhibitor against purified MEK, exhibiting a Ki of 1 nM against activated MEK1 and MEK2.  It has been shown that 1 µM PD0325901 combined with 3 µM CHIR99021 (2i) prevents cell differentiation and sustains self-renewal of murine embryonic stem cells.


Ref:  Barret, S.D., Bridges, A.J., Dudley, D.T., et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett 18 6501-6504, 2008.
Ying, Q., Wray, J., Nichols, J., et al. The ground state of embryonic stem cell self-renewal. Nature 453 519-524, 2008.