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  • LY47-002, 2 mg47.00
  • LY47-010, 10 mg147.00
  • LY47-050, 50 mg547.00
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Source M.W.272.3 CAS No.396129-53-6
Structural Info[3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole
ReconstitutionBefore reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube.  The compound is soluble in DMSO.
StabilityThe powder is stable for at least 2 year if stored at -20 °C. The dissolved compound is stable for at least 1 month at 4 °C, but should be stored in aliquots at -20 °C for longer term. Protect from light.
PurityGreater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological ActivityIn a cell-based assay measuring the activation of a SMAD reporter gene, this compound gives IC50 around 100-200 nM.
Country of OriginUSA

Selective inhibitor of TGF-β type-I receptor (IC50 59 nM for TGF-β RI vs. 400 nM for TGF-β RII).  

Ref:  Sawyer et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-μ type I receptor kinase domain. J. Med. Chem. 46 3953, 2003.