|Reconstitution||Before reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube. The compound is soluble in DMSO.|
|Stability||The powder is stable for at least 2 year if stored at -20 °C. The dissolved compound is stable for at least 1 month at 4 °C, but should be stored in aliquots at -20 °C for longer term. Protect from light.|
|Purity||Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.|
|Biological Activity||In a cell-based assay measuring the activation of a SMAD reporter gene, this compound gives IC50 around 100-200 nM.|
|Country of Origin||USA|
Selective inhibitor of TGF-β type-I receptor (IC50 59 nM for TGF-β RI vs. 400 nM for TGF-β RII).
Ref: Sawyer et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-μ type I receptor kinase domain. J. Med. Chem. 46 3953, 2003.