Jagged-1 Fc fusion, human

$ 281.00

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  • JAGGFC-050, 50 µg281.00
  • JAGGFC-1000, 1000 µg2981.00
  • JAGGFC-250, 250 µg981.00
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Sourcehuman 293 cells M.W.~180 kDa CAS No.
Structural Info
FormulationLyophilized in a sterile solution of PBS.
ReconstitutionBefore reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube.  The lyophilized peptide should be reconstituted in sterile water.
StabilityThe lyophilized protein is stable for at least 1 year if stored at -80 °C. Reconstituted protein is stable for at least 1 month at 4 °C, but should be stored in aliquots at -80°C for longer term.  Avoid repeated freeze and thaw.
PurityGreater than 90% as determined by SDS-PAGE analysis
Biological ActivityDetermined by a Notch pathway specific reporter gene assay. EC50s are in the range of 200 – 1000 ng/mL.
Country of OriginUSA

The Notch pathway is an important pathway in stem cell functions. Jagged-1, a ligand for Notch receptors, is a 180kDa type 1 membrane glycoprotein of the Delta/Serrate/Lag2 (DSL) family. 

StemRD’s Jagged-1 Fc fusion protein is expressed in human 293 cells as the 1046aa N-terminal extracellular domain of Jagged-1 fused to the Fc domain of human IgG1.  This fusion stabilizes Jagged-1 in vitro and in vivo without significant compromise in its biological activity.