GDC-0941, PI3 kinase inhibitor

$ 69.00

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  • G941-005, 5 mg69.00
  • G941-025, 25 mg169.00
  • G941-100, 100 mg469.00
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Source M.W.513.64 CAS No.957054-30-7
Structural Info
ReconstitutionBefore reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube.  The compound is soluble in DMSO.  Poorly Soluble in water. Dilution into protein-containing aqueous media is recommended.
StabilityThe powder is stable for at least 2 year if stored at -20 °C. The dissolved compound is stable for at least 1 month at 4 °C, but should be stored in aliquots at -20 °C for longer term. Protect from light.
PurityGreater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity
Country of OriginUSA

Chemical Name:  2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-

GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM,
respectively.  Administration of GDC-0941 in animals displays significant inhibitory effect against established human cancer
xenografts.  It is currently in clinical trials. PI3K inhibitors have been used for differentiation of pluripotent stem cells.
Ref:  Folkes AJ, et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.  Med Chem 51(18):5522-32, 2008
Touboul, et al. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development. Hepatology, 51: 1754–1765, 2010