Follistatin like-3 Fc fusion, human recombinant

$ 395.00

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  • FL3FC-050, 50 µg395.00
  • FL3FC-1000, 1000 µg2995.00
  • FL3FC-250, 250 µg1595.00
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SourceHuman 293 Cells M.W. CAS No.
Structural Info
FormulationLyophilized in sterile filtered solution of PBS.
ReconstitutionBefore reconstitution, a brief spin is recommend to drive down any material dislodged from the bottom of the tube.  The lyophilized protein should be reconstituted in sterile H2O to a desired concentration.  
StabilityThe lyophilized protein is stable for at least one year if stored at -80 °C.  Reconstituted protein is stable for at least four
weeks at 4 °C, but should be stored in aliquots at -80 °C for longer term.  Avoid repeated freeze and thaw.
PurityGreater than 95% as determined by SDS-PAGE analysis
Biological ActivityThe activity was determined by using a SMAD reporter gene assay in cultured human cells. The IC50 ranges from 100 - 500 ng/ml in the inhibition of 1 ng/mL Activin A activity.
Country of OriginUSA

Follistatin like 3 is a homolog of Follistatin which is a secreted protein that binds to some members of the TGF-β family and blocks their access to corresponding receptors.  In addition to being a natural antagonist of Activins, Follistatin like 3 may
inhibit the activity of other TGF-β ligands including BMPs, Myostatin, GDF-11, and TGF-β1.

StemRD’s Follistatin like 3 Fc fusion protein is full-length human Follistain like 3 fused to the N-terminus of the Fc domain of human IgG1.  This fusion allows stabilization of the protein in vitro and in vivo and dimerization of the recombinant protein rendering high-affinity binding to Activins.  

Expression is in human 293 cells cultured in serum-free and protein-free medium. Purification of the fusion protein from culture medium is achieved by using protein A chromatography.